@inbook{6cef9ebd0cf84465982526f35a41b29e,
title = "Visualization of protein-protein interaction networks using force-directed layout",
abstract = "Protein interactions, when visualized as an undirected graph, often yield a nonplanar, disconnected graph with nodes of wide range of degrees. Many graph-drawing programs are of limited use in visualizing protein interactions, either because they are too slow, or because they produce a cluttered drawing with many edge crossings or a static drawing that is not easy to modify to reflect changes in data. We have developed a new force-directed layout algorithm for drawing protein interactions in three-dimensional space. Our algorithm divides nodes into three groups based on their interacting properties: biconnected subgraph in the center, terminal nodes at the outermost region, and the rest in between them. Experimental results show that our algorithm efficiently generates a clear and aesthetically pleasing drawing of large-scale protein interaction networks and that it is much faster than other force-directed layouts.",
author = "Yanga Byun and Kyungsook Han",
year = "2003",
doi = "10.1007/3-540-44863-2_20",
language = "English",
isbn = "9783540401964",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "190--199",
editor = "Sloot, {Peter M.A.} and David Abramson and Bogdanov, {Alexander V.} and Gorbachev, {Yuriy E.} and Dongarra, {Jack J.} and Zomaya, {Albert Y.}",
booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
address = "Germany",
}