Visualization of human retinal capillary networks: A comparison of intensity, speckle-variance and phase-variance optical coherence tomography

Dae Yu Kim, Jeff Fingler, John S. Werner, Daniel M. Schwartz, Scott E. Fraser, Robert J. Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We evaluate methods to visualize human retinal micro-circulation in vivo by standard intensity-based optical coherence tomography (OCT), speckle-variance optical coherence tomography (svOCT), and phase-variance optical coherence tomography (pvOCT). En face projection views created from the same volumetric data set of the human retina using all three data processing methods are created and compared. Additionally we used support vector machine (SVM) based semi-automatic segmentation to generate en face projection views of individual retinal layers. The layers include: first, the whole inner retina (from the nerve fiber layer to the outer nuclear layer), and second, from the ganglion cell layer to the outer nuclear layer. Finally, we compare the retinal vasculature images processed from the three OCT techniques and fluorescein angiography (FA).

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
PublisherSPIE
ISBN (Print)9780819488565
DOIs
StatePublished - 2012
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: 23 Jan 201225 Jan 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8213
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Country/TerritoryUnited States
CitySan Francisco, CA
Period23/01/1225/01/12

Keywords

  • Imaging system
  • Medical optics instrumentation
  • Optical coherence tomography
  • Phase contrast technique

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