Taurine Chloramine Inhibits Leukocyte Migration by Suppressing Actin Polymerization and Extracellular Signal-Regulated Kinase

Hyun Jae Kim, In Soon Kang, Chaekyun Kim

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Taurine, one of the most abundant amino acids, is ubiquitously distributed in mammalian tissues and is known to react with myeloperoxidase-derived hypochlorous acid (HOCl/OCl-) to produce taurine chloramine (Tau-Cl), which prevents inflammation by both suppressing pro-inflammatory mediators and increasing antioxidant levels. The migration of inflammatory cells, including neutrophils and macrophages, to infection sites is critical to the development of inflammation. In the present study, we investigated whether Tau-Cl suppresses the migration of inflammatory cells. Tau-Cl inhibited thioglycollate-induced leukocyte migration to the peritoneal cavity, as well as both fMLP-induced neutrophil migration and LPS-stimulated macrophage migration in a transwell system. Tau-Cl also inhibited LPS-induced actin polymerization, adhesion, and ERK phosphorylation in macrophages. Together, these findings suggest that Tau-Cl inhibits the infiltration of inflammatory cells into infection sites by inhibiting ERK activation, thereby preventing actin polymerization, and thus, the excessive infiltration of inflammatory cells, which can cause chronic inflammation.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages51-61
Number of pages11
DOIs
StatePublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1370
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

  • Actin polymerization
  • Inflammation
  • Macrophages
  • Migration
  • Neutrophils
  • Taurine chloramine

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