Abstract
Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O 2•-, H2O2 and NO. In this study, RAW 264.7 macrophages treated with TauCl were protected from death caused by H2O2. TauCl increased the expression of peroxiredoxin-1, thioredoxin-1 and heme oxygenase (HO)-1, the anti-oxidant enzymes normally induced by activation of NF-E2-related factor-2 (Nrf2). TauCl increased nuclear translocation of Nrf2 and binding to the anti-oxidant response element. These data suggest that TauCl produced abundantly in the activated neutrophils and released to surrounding cells in the inflamed tissues may induce the expression of cytoprotective anti-oxidant enzymes. Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H 2O2.
Original language | English |
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Pages (from-to) | 37-43 |
Number of pages | 7 |
Journal | Journal of Clinical Biochemistry and Nutrition |
Volume | 45 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2009 |
Keywords
- Cell death
- Heme oxygenase-1
- Hydrogen peroxide
- Nuclear factor-erythroid 2-related factor 2
- Taurine chloramine