Taurine chloramine activates Nrf2, increases HO-1 expression and protects cells from death caused by hydrogen peroxide

Sun Jang Jin, Shuyu Piao, Young Nam Cha, Chaekyun Kim

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O 2•-, H2O2 and NO. In this study, RAW 264.7 macrophages treated with TauCl were protected from death caused by H2O2. TauCl increased the expression of peroxiredoxin-1, thioredoxin-1 and heme oxygenase (HO)-1, the anti-oxidant enzymes normally induced by activation of NF-E2-related factor-2 (Nrf2). TauCl increased nuclear translocation of Nrf2 and binding to the anti-oxidant response element. These data suggest that TauCl produced abundantly in the activated neutrophils and released to surrounding cells in the inflamed tissues may induce the expression of cytoprotective anti-oxidant enzymes. Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H 2O2.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume45
Issue number1
DOIs
StatePublished - Jul 2009

Keywords

  • Cell death
  • Heme oxygenase-1
  • Hydrogen peroxide
  • Nuclear factor-erythroid 2-related factor 2
  • Taurine chloramine

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