Abstract
Introduction: L-type amino acid transporter 1 (LAT1) is one of the amino acid transporters. It is overexpressed in various types of cancer cells, while it is produced restrictedly in normal tissues.Areas covered: We discuss its characteristics in cancer cells compared with normal cells. We also mention the current applications to target LAT1 for anticancer therapy focusing on prognostic biomarkers, radio-labeled tumor imaging reagents, amino acid-stapled prodrugs, LAT1-mediated enhanced transport of anticancer drugs and LAT1 inhibitors.Expert opinion: LAT1 can be a versatile target to promisingly develop transporter-based drugs with enhanced drug delivery potential for anticancer therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 1319-1337 |
| Number of pages | 19 |
| Journal | Expert Opinion on Therapeutic Targets |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| State | Published - 3 Oct 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Informa UK, Ltd.
Keywords
- L-type amino acid transporter 1
- anticancer drug
- cancer
- inhibitor
- prodrug
- prognostic biomarker
- tumor imaging
