Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2

Chang Young Kim; Hyun Joo Park; Yeo Joon Yoon; Han Young Kang; Eung Soo Kim

Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2

Chang Young Kim, Hyun Joo Park, Yeo Joon Yoon, Han Young Kang, Eung Soo Kim

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Abstract

An actinorhodin nonproducing Streptomyces lividans was converted to an actinorhodin overproducer through a single chromosomal integration of an antibiotic regulatory gene, afsR2. This strain exhibited early actinorhodin production and an average of 37.5% higher productivity than the S. lividans containing multiple copies of afsR2 plasmid in a glucose-containing liquid culture.

Original language	English
Pages (from-to)	1089-1092
Number of pages	4
Journal	Journal of Microbiology and Biotechnology
Volume	14
Issue number	5
State	Published - Oct 2004

Keywords

Actinorhodin
Chromosomal integration
Streptomyces lividans
afsR2

Cite this

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title = "Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2",

abstract = "An actinorhodin nonproducing Streptomyces lividans was converted to an actinorhodin overproducer through a single chromosomal integration of an antibiotic regulatory gene, afsR2. This strain exhibited early actinorhodin production and an average of 37.5% higher productivity than the S. lividans containing multiple copies of afsR2 plasmid in a glucose-containing liquid culture.",

keywords = "Actinorhodin, Chromosomal integration, Streptomyces lividans, afsR2",

author = "Kim, {Chang Young} and Park, {Hyun Joo} and Yoon, {Yeo Joon} and Kang, {Han Young} and Kim, {Eung Soo}",

year = "2004",

month = oct,

language = "English",

volume = "14",

pages = "1089--1092",

journal = "Journal of Microbiology and Biotechnology",

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T1 - Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2

AU - Kim, Chang Young

AU - Park, Hyun Joo

AU - Yoon, Yeo Joon

AU - Kang, Han Young

AU - Kim, Eung Soo

PY - 2004/10

Y1 - 2004/10

N2 - An actinorhodin nonproducing Streptomyces lividans was converted to an actinorhodin overproducer through a single chromosomal integration of an antibiotic regulatory gene, afsR2. This strain exhibited early actinorhodin production and an average of 37.5% higher productivity than the S. lividans containing multiple copies of afsR2 plasmid in a glucose-containing liquid culture.

AB - An actinorhodin nonproducing Streptomyces lividans was converted to an actinorhodin overproducer through a single chromosomal integration of an antibiotic regulatory gene, afsR2. This strain exhibited early actinorhodin production and an average of 37.5% higher productivity than the S. lividans containing multiple copies of afsR2 plasmid in a glucose-containing liquid culture.

KW - Actinorhodin

KW - Chromosomal integration

KW - Streptomyces lividans

KW - afsR2

UR - http://www.scopus.com/inward/record.url?scp=8644246825&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:8644246825

SN - 1017-7825

VL - 14

SP - 1089

EP - 1092

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 5

ER -

Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2

Abstract

Keywords

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