Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Wei Dong Xie; Xiu Ru Wang; Li Sha Ma; Xia Li; Kyung Ho Row

doi:10.1016/j.fitote.2012.04.016

Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Wei Dong Xie, Xiu Ru Wang, Li Sha Ma, Xia Li, Kyung Ho Row

Shandong University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy- 7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.

Original language	English
Pages (from-to)	1351-1355
Number of pages	5
Journal	Fitoterapia
Volume	83
Issue number	8
DOIs	https://doi.org/10.1016/j.fitote.2012.04.016
State	Published - Dec 2012

Bibliographical note

Funding Information:
This work was supported by the Natural Science Foundation of Shandong Province, PR China (No. 2009ZRB02091 ) and the National Natural Science Foundation of China (No. 81072660 ).

Keywords

Carpesium divaricatum
Cytotoxicity
Eudesmane
Lactone
Sesquiterpenoid

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fitote.2012.04.016

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@article{ec3390f3b05f463e86bd4ac77dabc6de,

title = "Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity",

abstract = "In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy- 7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.",

keywords = "Carpesium divaricatum, Cytotoxicity, Eudesmane, Lactone, Sesquiterpenoid",

author = "Xie, \{Wei Dong\} and Wang, \{Xiu Ru\} and Ma, \{Li Sha\} and Xia Li and Row, \{Kyung Ho\}",

note = "Funding Information: This work was supported by the Natural Science Foundation of Shandong Province, PR China (No. 2009ZRB02091 ) and the National Natural Science Foundation of China (No. 81072660 ). ",

year = "2012",

month = dec,

doi = "10.1016/j.fitote.2012.04.016",

language = "English",

volume = "83",

pages = "1351--1355",

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T1 - Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

AU - Xie, Wei Dong

AU - Wang, Xiu Ru

AU - Ma, Li Sha

AU - Li, Xia

AU - Row, Kyung Ho

N1 - Funding Information: This work was supported by the Natural Science Foundation of Shandong Province, PR China (No. 2009ZRB02091 ) and the National Natural Science Foundation of China (No. 81072660 ).

PY - 2012/12

Y1 - 2012/12

N2 - In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy- 7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.

AB - In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy- 7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.

KW - Carpesium divaricatum

KW - Cytotoxicity

KW - Eudesmane

KW - Lactone

KW - Sesquiterpenoid

UR - https://www.scopus.com/pages/publications/84870771647

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DO - 10.1016/j.fitote.2012.04.016

M3 - Article

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AN - SCOPUS:84870771647

SN - 0367-326X

VL - 83

SP - 1351

EP - 1355

JO - Fitoterapia

JF - Fitoterapia

IS - 8

ER -

Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Abstract

Bibliographical note

Keywords

UN SDGs

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