Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Hyun Yoo; Byeongwook Jeon; Myung Shin Jeon; Hyangkyu Lee; Tae Yoon Kim

doi:10.1016/j.febslet.2008.08.017

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Hyun Yoo, Byeongwook Jeon, Myung Shin Jeon, Hyangkyu Lee, Tae Yoon Kim

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

Original language	English
Pages (from-to)	3249-3253
Number of pages	5
Journal	FEBS Letters
Volume	582
Issue number	21-22
DOIs	https://doi.org/10.1016/j.febslet.2008.08.017
State	Published - 22 Sep 2008
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.

Keywords

12/15-Lipoxygenase (LOX)
HaCaT
IGF-II
Psoriasis
UV

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10.1016/j.febslet.2008.08.017

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title = "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes",

abstract = "The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.",

keywords = "12/15-Lipoxygenase (LOX), HaCaT, IGF-II, Psoriasis, UV",

author = "Hyun Yoo and Byeongwook Jeon and Jeon, {Myung Shin} and Hyangkyu Lee and Kim, {Tae Yoon}",

note = "Funding Information: This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.",

year = "2008",

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doi = "10.1016/j.febslet.2008.08.017",

language = "English",

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T1 - Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

AU - Yoo, Hyun

AU - Jeon, Byeongwook

AU - Jeon, Myung Shin

AU - Lee, Hyangkyu

AU - Kim, Tae Yoon

N1 - Funding Information: This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.

PY - 2008/9/22

Y1 - 2008/9/22

N2 - The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

AB - The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

KW - 12/15-Lipoxygenase (LOX)

KW - HaCaT

KW - IGF-II

KW - Psoriasis

KW - UV

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U2 - 10.1016/j.febslet.2008.08.017

DO - 10.1016/j.febslet.2008.08.017

M3 - Article

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AN - SCOPUS:51249120070

SN - 0014-5793

VL - 582

SP - 3249

EP - 3253

JO - FEBS Letters

JF - FEBS Letters

IS - 21-22

ER -

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Abstract

Bibliographical note

Keywords

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