Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats

Hee Seung Lee; Kyung Hee Jung; In Suh Park; Sung Won Kwon; Don Haeng Lee; Soon Sun Hong

doi:10.1007/s10620-008-0404-x

Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats

Hee Seung Lee, Kyung Hee Jung, In Suh Park, Sung Won Kwon, Don Haeng Lee, Soon Sun Hong

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor β₁ (TGF-β₁), and α-smooth muscle actin (α-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-β₁, and α-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.

Original language	English
Pages (from-to)	782-788
Number of pages	7
Journal	Digestive Diseases and Sciences
Volume	54
Issue number	4
DOIs	https://doi.org/10.1007/s10620-008-0404-x
State	Published - Apr 2009
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by an Inha University

Keywords

Antioxidant
Dimethylnitrosamine
Hepatic fibrosis
Morin

Access to Document

10.1007/s10620-008-0404-x

Cite this

@article{3b202c158a8c468ca02b4b235bbecb5d,

title = "Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats",

abstract = "Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor β1 (TGF-β1), and α-smooth muscle actin (α-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-β1, and α-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.",

keywords = "Antioxidant, Dimethylnitrosamine, Hepatic fibrosis, Morin",

author = "Lee, {Hee Seung} and Jung, {Kyung Hee} and Park, {In Suh} and Kwon, {Sung Won} and Lee, {Don Haeng} and Hong, {Soon Sun}",

note = "Funding Information: This work was supported by an Inha University",

year = "2009",

month = apr,

doi = "10.1007/s10620-008-0404-x",

language = "English",

volume = "54",

pages = "782--788",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats

AU - Lee, Hee Seung

AU - Jung, Kyung Hee

AU - Park, In Suh

AU - Kwon, Sung Won

AU - Lee, Don Haeng

AU - Hong, Soon Sun

N1 - Funding Information: This work was supported by an Inha University

PY - 2009/4

Y1 - 2009/4

N2 - Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor β1 (TGF-β1), and α-smooth muscle actin (α-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-β1, and α-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.

AB - Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor β1 (TGF-β1), and α-smooth muscle actin (α-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-β1, and α-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.

KW - Antioxidant

KW - Dimethylnitrosamine

KW - Hepatic fibrosis

KW - Morin

UR - http://www.scopus.com/inward/record.url?scp=63249101797&partnerID=8YFLogxK

U2 - 10.1007/s10620-008-0404-x

DO - 10.1007/s10620-008-0404-x

M3 - Article

C2 - 18629640

AN - SCOPUS:63249101797

SN - 0163-2116

VL - 54

SP - 782

EP - 788

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 4

ER -

Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this