TY - JOUR
T1 - Photoactivable liposomes for controlled delivery
T2 - Recent progress and design considerations
AU - Song, Seoyoon
AU - Lee, Deborah
AU - Dalle Ore, Lucia C.
AU - Kwak, Sungjun
AU - Kang, Lifeng
AU - Kim, Hyung Kyo
AU - Malmstadt, Noah
AU - Kim, Sun Min
AU - Jeon, Tae Joon
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Recent strides in drug delivery have aimed at precise control over therapeutic agent release and targeting. Liposomes, lipid-based vesicles, have stood out for their capacity to encapsulate diverse agents. While their structural features offer biocompatibility and stability, the inability to provide on-demand drug release limits their efficacy. Addressing these limitations, photoactivable liposomes, leveraging light as a trigger, offer a compelling solution. This strategy surpasses established controlled systems, providing spatiotemporal precision and non-invasive external triggering. Furthermore, the versatility of photoactivation, achieved through the manipulation of light-responsive components, enables meticulous control over release kinetics. While extant reviews predominantly concentrate on release strategies and materials, this paper takes a novel approach by spotlighting recent advancements in categorized photoactivable liposomes. Moreover, drawing from contemporary illustrations, the article accentuates design considerations that encompass physicochemical properties and light-related constituents. These insights collectively contribute to the evolution of sophisticated drug delivery systems.
AB - Recent strides in drug delivery have aimed at precise control over therapeutic agent release and targeting. Liposomes, lipid-based vesicles, have stood out for their capacity to encapsulate diverse agents. While their structural features offer biocompatibility and stability, the inability to provide on-demand drug release limits their efficacy. Addressing these limitations, photoactivable liposomes, leveraging light as a trigger, offer a compelling solution. This strategy surpasses established controlled systems, providing spatiotemporal precision and non-invasive external triggering. Furthermore, the versatility of photoactivation, achieved through the manipulation of light-responsive components, enables meticulous control over release kinetics. While extant reviews predominantly concentrate on release strategies and materials, this paper takes a novel approach by spotlighting recent advancements in categorized photoactivable liposomes. Moreover, drawing from contemporary illustrations, the article accentuates design considerations that encompass physicochemical properties and light-related constituents. These insights collectively contribute to the evolution of sophisticated drug delivery systems.
KW - Drug delivery
KW - Light-triggered release
KW - Liposomes
KW - Photoactivation
UR - http://www.scopus.com/inward/record.url?scp=85182216412&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2023.215567
DO - 10.1016/j.ccr.2023.215567
M3 - Review article
AN - SCOPUS:85182216412
SN - 0010-8545
VL - 501
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 215567
ER -