PH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

Min Sang Kim; Su Jong Hwang; Jong Kwon Han; Eun Kyung Choi; Heon Joo Park; Jin Seok Kim; Doo Sung Lee

doi:10.1002/marc.200500769

PH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

Min Sang Kim, Su Jong Hwang, Jong Kwon Han, Eun Kyung Choi, Heon Joo Park, Jin Seok Kim, Doo Sung Lee

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellizationdemicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and Hydrophobie but pH-sensitive poly(β-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(β-amino ester).

Original language	English
Pages (from-to)	447-451
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	27
Issue number	6
DOIs	https://doi.org/10.1002/marc.200500769
State	Published - 24 Mar 2006
Externally published	Yes

Keywords

Block copolymers
Micelles
PH-sensitive polymer
PK value
Poly(β-amino esters)
Polymeric micelle

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10.1002/marc.200500769

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abstract = "A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellizationdemicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and Hydrophobie but pH-sensitive poly(β-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(β-amino ester).",

keywords = "Block copolymers, Micelles, PH-sensitive polymer, PK value, Poly(β-amino esters), Polymeric micelle",

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AU - Kim, Min Sang

AU - Hwang, Su Jong

AU - Han, Jong Kwon

AU - Choi, Eun Kyung

AU - Park, Heon Joo

AU - Kim, Jin Seok

AU - Lee, Doo Sung

PY - 2006/3/24

Y1 - 2006/3/24

N2 - A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellizationdemicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and Hydrophobie but pH-sensitive poly(β-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(β-amino ester).

AB - A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellizationdemicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and Hydrophobie but pH-sensitive poly(β-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(β-amino ester).

KW - Block copolymers

KW - Micelles

KW - PH-sensitive polymer

KW - PK value

KW - Poly(β-amino esters)

KW - Polymeric micelle

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JO - Macromolecular Rapid Communications

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ER -

PH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

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Keywords

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