TY - JOUR
T1 - Nanoparticles mediated tumor microenvironment modulation
T2 - current advances and applications
AU - Raju, Ganji Seeta Rama
AU - Pavitra, Eluri
AU - Varaprasad, Ganji Lakshmi
AU - Bandaru, Sai Samyuktha
AU - Nagaraju, Ganji Purnachandra
AU - Farran, Batoul
AU - Huh, Yun Suk
AU - Han, Young Kyu
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and resensitizing resistant neoplastic niches to existing cancer therapies such as immunotherapy or chemotherapy. Nano-based solutions have important advantages over traditional platform and can be specifically targeted and delivered to desired sites. This review explores novel nano-based approaches aimed at targeting and reprogramming aberrant TME components such as macrophages, fibroblasts, tumor vasculature, hypoxia and ROS pathways. We also discuss how nanoplatforms can be combined with existing anti-tumor regimens such as radiotherapy, immunotherapy, phototherapy or chemotherapy to enhance clinical outcomes in solid tumors.
AB - The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and resensitizing resistant neoplastic niches to existing cancer therapies such as immunotherapy or chemotherapy. Nano-based solutions have important advantages over traditional platform and can be specifically targeted and delivered to desired sites. This review explores novel nano-based approaches aimed at targeting and reprogramming aberrant TME components such as macrophages, fibroblasts, tumor vasculature, hypoxia and ROS pathways. We also discuss how nanoplatforms can be combined with existing anti-tumor regimens such as radiotherapy, immunotherapy, phototherapy or chemotherapy to enhance clinical outcomes in solid tumors.
KW - Chemotherapy
KW - Drug delivery
KW - Immunotherapy
KW - Nanoparticles
KW - Photodynamic therapy
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85131879636&partnerID=8YFLogxK
U2 - 10.1186/s12951-022-01476-9
DO - 10.1186/s12951-022-01476-9
M3 - Review article
C2 - 35701781
AN - SCOPUS:85131879636
SN - 1477-3155
VL - 20
JO - Journal of Nanobiotechnology
JF - Journal of Nanobiotechnology
IS - 1
M1 - 274
ER -
