Nanoparticles for diagnosis and treatment of hepatocellular carcinoma

Primary liver cancer universally continues to be one of the leading causes of health problem. Hepatocellular carcinoma (HCC), is a prominent form of primary liver cancer, is also the major cause of cancer-related death worldwide due to lack of proper diagnosis at the early stage of the disease and scarce of appropriate treatment tools. Thus there is high demand for a novel therapeutic approach to treat HCC. Nanotechnology is presently a fast-growing field which offers infinite prospects to design nanoscale products with imaging, diagnosis, and treatment purpose. Forty-five papers were included in the review, most of them contributed latest research related to nanoparticle-based targeted therapy for HCC cancer. Nanoparticles with significant therapeutic potential in clinical trials have been discussed and some of the major limitations are also addressed.