Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

Hee Seung Lee; Kyung Hee Jung; Sang Won Hong; In Suh Park; Chongmu Lee; Hyo Kyung Han; Don Haeng Lee; Soon Sun Hong

doi:10.1007/s12272-001-1283-5

Morin protects acute liver damage by carbon tetrachloride (CCl₄) in rat

Hee Seung Lee, Kyung Hee Jung, Sang Won Hong, In Suh Park, Chongmu Lee, Hyo Kyung Han, Don Haeng Lee, Soon Sun Hong

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The purpose of this study was to investigate possible beneficial effects of morin on CCl₄-induced acute hepatotoxicity in rats. Rats received a single dose of CCl₄ (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl₄ administration. CCl₄ challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl₄-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl₄ treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.

Original language	English
Pages (from-to)	1160-1165
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	31
Issue number	9
DOIs	https://doi.org/10.1007/s12272-001-1283-5
State	Published - Sep 2008
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by Inha University Research Grant.

Keywords

Antioxidant
Carbon tetrachloride (CCl)
Hepatic toxicity
Morin

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10.1007/s12272-001-1283-5

Cite this

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title = "Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat",

abstract = "The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.",

keywords = "Antioxidant, Carbon tetrachloride (CCl), Hepatic toxicity, Morin",

author = "Lee, {Hee Seung} and Jung, {Kyung Hee} and Hong, {Sang Won} and Park, {In Suh} and Chongmu Lee and Han, {Hyo Kyung} and Lee, {Don Haeng} and Hong, {Soon Sun}",

note = "Funding Information: This work was supported by Inha University Research Grant.",

year = "2008",

month = sep,

doi = "10.1007/s12272-001-1283-5",

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T1 - Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

AU - Lee, Hee Seung

AU - Jung, Kyung Hee

AU - Hong, Sang Won

AU - Park, In Suh

AU - Lee, Chongmu

AU - Han, Hyo Kyung

AU - Lee, Don Haeng

AU - Hong, Soon Sun

N1 - Funding Information: This work was supported by Inha University Research Grant.

PY - 2008/9

Y1 - 2008/9

N2 - The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.

AB - The purpose of this study was to investigate possible beneficial effects of morin on CCl4-induced acute hepatotoxicity in rats. Rats received a single dose of CCl4 (150 μL/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl4 challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl4-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-α, IL-1β, IL-6, and iNOS were increased by CCl4 treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-α, IL-1β, IL-6, and iNOS.

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KW - Hepatic toxicity

KW - Morin

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