Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control

Sang Kim Min; Sung Lee Doo; Eun Kyung Choi; Heon Joo Park; Jin Seok Kim

doi:10.1007/bf03219029

Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control

Sang Kim Min, Sung Lee Doo, Eun Kyung Choi, Heon Joo Park, Jin Seok Kim

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The main objective of this study was to modulate pH-sensitive polymers (poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by ¹H-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	Macromolecular Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/bf03219029
State	Published - Apr 2005
Externally published	Yes

Keywords

Molecular weight control
pH-sensitive polymer

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10.1007/bf03219029

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title = "Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control",

abstract = "The main objective of this study was to modulate pH-sensitive polymers (poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by 1H-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.",

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author = "Min, {Sang Kim} and Doo, {Sung Lee} and Choi, {Eun Kyung} and Park, {Heon Joo} and Kim, {Jin Seok}",

year = "2005",

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doi = "10.1007/bf03219029",

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journal = "Macromolecular Research",

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T1 - Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control

AU - Min, Sang Kim

AU - Doo, Sung Lee

AU - Choi, Eun Kyung

AU - Park, Heon Joo

AU - Kim, Jin Seok

PY - 2005/4

Y1 - 2005/4

N2 - The main objective of this study was to modulate pH-sensitive polymers (poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by 1H-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.

AB - The main objective of this study was to modulate pH-sensitive polymers (poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by 1H-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.

KW - Molecular weight control

KW - pH-sensitive polymer

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U2 - 10.1007/bf03219029

DO - 10.1007/bf03219029

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SP - 147

EP - 151

JO - Macromolecular Research

JF - Macromolecular Research

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Modulation of poly(β-amino ester) pH-sensitive polymers by molecular weight control

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Keywords

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