Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

Sang Bong Lee; Hye Lan Kim; Hwan Jeong Jeong; Seok Tae Lim; Myung Hee Sohn; Dong Wook Kim

doi:10.1002/anie.201304026

Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

Sang Bong Lee, Hye Lan Kim, Hwan Jeong Jeong, Seok Tae Lim, Myung Hee Sohn, Dong Wook Kim

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.

Original language	English
Pages (from-to)	10549-10552
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	40
DOIs	https://doi.org/10.1002/anie.201304026
State	Published - 27 Sep 2013

Keywords

bioorthogonal reactions
mesoporous silica
molecular imaging
nanoparticles
radiopharmaceuticals

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10.1002/anie.201304026

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abstract = "Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.",

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AU - Lim, Seok Tae

AU - Sohn, Myung Hee

AU - Kim, Dong Wook

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KW - mesoporous silica

KW - molecular imaging

KW - nanoparticles

KW - radiopharmaceuticals

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Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

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Keywords

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