TY - JOUR
T1 - In-vitro and in-vivo behaviors of poly(glycolide-caprolactone) copolymer for bioabsorbable suture materials
AU - Yoo, Yeon Chun
AU - Kim, Hak Yong
AU - Jin, Fan Long
AU - Park, Soo Jin
PY - 2012/12/20
Y1 - 2012/12/20
N2 - A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.
AB - A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.
KW - Absorbable suture
KW - Biocompatibility
KW - Monofilament
KW - Poly(glycolide-caprolactone)
UR - http://www.scopus.com/inward/record.url?scp=84871791750&partnerID=8YFLogxK
U2 - 10.5012/bkcs.2012.33.12.4137
DO - 10.5012/bkcs.2012.33.12.4137
M3 - Article
AN - SCOPUS:84871791750
SN - 0253-2964
VL - 33
SP - 4137
EP - 4140
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
IS - 12
ER -