Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

Chan Hee Park; Jongwon Lee; Hwi Young Jung; Min Ji Kim; Sun Ha Lim; Hyung Tae Yeo; Eung Chil Choi; Eun Jeong Yoon; Kyu Won Kim; Jong Ho Cha; Seok Ho Kim; Dong Jo Chang; Do Yeon Kwon; Funan Li; Young Ger Suh

doi:10.1016/j.bmc.2007.07.009

Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

Chan Hee Park, Jongwon Lee, Hwi Young Jung, Min Ji Kim, Sun Ha Lim, Hyung Tae Yeo, Eung Chil Choi, Eun Jeong Yoon, Kyu Won Kim, Jong Ho Cha, Seok Ho Kim, Dong Jo Chang, Do Yeon Kwon, Funan Li, Young Ger Suh

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.

Original language	English
Pages (from-to)	6517-6526
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	15
Issue number	20
DOIs	https://doi.org/10.1016/j.bmc.2007.07.009
State	Published - 15 Oct 2007
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a grant from the Seoul R& BD Program and the Research Institute of Medical Science, Catholic University of Daegu.

Keywords

Anti-apoptotic activity
Anti-ischemic agents
MCAO
MI
Quinolone analog
Structure-activity relationship

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10.1016/j.bmc.2007.07.009

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Park, C. H., Lee, J., Jung, H. Y., Kim, M. J., Lim, S. H., Yeo, H. T., Choi, E. C., Yoon, E. J., Kim, K. W., Cha, J. H., Kim, S. H., Chang, D. J., Kwon, D. Y., Li, F., & Suh, Y. G. (2007). Identification, biological activity, and mechanism of the anti-ischemic quinolone analog. Bioorganic and Medicinal Chemistry, 15(20), 6517-6526. https://doi.org/10.1016/j.bmc.2007.07.009

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title = "Identification, biological activity, and mechanism of the anti-ischemic quinolone analog",

abstract = "The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.",

keywords = "Anti-apoptotic activity, Anti-ischemic agents, MCAO, MI, Quinolone analog, Structure-activity relationship",

author = "Park, {Chan Hee} and Jongwon Lee and Jung, {Hwi Young} and Kim, {Min Ji} and Lim, {Sun Ha} and Yeo, {Hyung Tae} and Choi, {Eung Chil} and Yoon, {Eun Jeong} and Kim, {Kyu Won} and Cha, {Jong Ho} and Kim, {Seok Ho} and Chang, {Dong Jo} and Kwon, {Do Yeon} and Funan Li and Suh, {Young Ger}",

note = "Funding Information: This work was supported by a grant from the Seoul R& BD Program and the Research Institute of Medical Science, Catholic University of Daegu.",

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doi = "10.1016/j.bmc.2007.07.009",

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AU - Lee, Jongwon

AU - Jung, Hwi Young

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AU - Lim, Sun Ha

AU - Yeo, Hyung Tae

AU - Choi, Eung Chil

AU - Yoon, Eun Jeong

AU - Kim, Kyu Won

AU - Cha, Jong Ho

AU - Kim, Seok Ho

AU - Chang, Dong Jo

AU - Kwon, Do Yeon

AU - Li, Funan

AU - Suh, Young Ger

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AB - The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.

KW - Anti-apoptotic activity

KW - Anti-ischemic agents

KW - MCAO

KW - MI

KW - Quinolone analog

KW - Structure-activity relationship

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Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

Abstract

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Keywords

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