Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide

Lok Nath Neupane; Ponnaboina Thirupathi; Sujung Jang; Min Jung Jang; Jung Hwa Kim; Keun Hyeung Lee

doi:10.1016/j.talanta.2011.06.052

Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide

Lok Nath Neupane, Ponnaboina Thirupathi, Sujung Jang, Min Jung Jang, Jung Hwa Kim, Keun Hyeung Lee

Inha University

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Fluorescent sensor (DMH) based on dipeptide was efficiently synthesized in solid phase synthesis. The dipeptide sensor shows sensitive response to Ag(I), Hg(II), and Cu(II) among 14 metal ions in 100% aqueous solution. The fluorescent sensor differentiates three heavy metal ions by response type; turn on response to Ag(I), ratiometric response to Hg(II), and turn off detection of Cu(II). The detection limits of the sensor for Ag(I) and Cu(II) were much lower than the EPA's drinking water maximum contaminant levels (MCL). Specially, DMH penetrated live cells and detected intracellular Ag⁺ by turn on response. We described the fluorescent change, binding affinity, detection limit for the metal ions. The study of a heavy metal-responsive sensor based on dipeptide demonstrates its potential utility in the environment field.

Original language	English
Pages (from-to)	1566-1574
Number of pages	9
Journal	Talanta
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/j.talanta.2011.06.052
State	Published - 15 Sep 2011

Bibliographical note

Funding Information:
This work was supported by a grant ( 2009-0076572 ) from the basic research program of National Research Foundation of Korea .

Keywords

Ag(I)
Fluorescent
Hg(II)
Peptide
Ratiometric
Sensor

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10.1016/j.talanta.2011.06.052

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title = "Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide",

abstract = "Fluorescent sensor (DMH) based on dipeptide was efficiently synthesized in solid phase synthesis. The dipeptide sensor shows sensitive response to Ag(I), Hg(II), and Cu(II) among 14 metal ions in 100\% aqueous solution. The fluorescent sensor differentiates three heavy metal ions by response type; turn on response to Ag(I), ratiometric response to Hg(II), and turn off detection of Cu(II). The detection limits of the sensor for Ag(I) and Cu(II) were much lower than the EPA's drinking water maximum contaminant levels (MCL). Specially, DMH penetrated live cells and detected intracellular Ag+ by turn on response. We described the fluorescent change, binding affinity, detection limit for the metal ions. The study of a heavy metal-responsive sensor based on dipeptide demonstrates its potential utility in the environment field.",

keywords = "Ag(I), Fluorescent, Hg(II), Peptide, Ratiometric, Sensor",

author = "Neupane, \{Lok Nath\} and Ponnaboina Thirupathi and Sujung Jang and Jang, \{Min Jung\} and Kim, \{Jung Hwa\} and Lee, \{Keun Hyeung\}",

note = "Funding Information: This work was supported by a grant ( 2009-0076572 ) from the basic research program of National Research Foundation of Korea . ",

year = "2011",

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doi = "10.1016/j.talanta.2011.06.052",

language = "English",

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T1 - Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide

AU - Neupane, Lok Nath

AU - Thirupathi, Ponnaboina

AU - Jang, Sujung

AU - Jang, Min Jung

AU - Kim, Jung Hwa

AU - Lee, Keun Hyeung

N1 - Funding Information: This work was supported by a grant ( 2009-0076572 ) from the basic research program of National Research Foundation of Korea .

PY - 2011/9/15

Y1 - 2011/9/15

N2 - Fluorescent sensor (DMH) based on dipeptide was efficiently synthesized in solid phase synthesis. The dipeptide sensor shows sensitive response to Ag(I), Hg(II), and Cu(II) among 14 metal ions in 100% aqueous solution. The fluorescent sensor differentiates three heavy metal ions by response type; turn on response to Ag(I), ratiometric response to Hg(II), and turn off detection of Cu(II). The detection limits of the sensor for Ag(I) and Cu(II) were much lower than the EPA's drinking water maximum contaminant levels (MCL). Specially, DMH penetrated live cells and detected intracellular Ag+ by turn on response. We described the fluorescent change, binding affinity, detection limit for the metal ions. The study of a heavy metal-responsive sensor based on dipeptide demonstrates its potential utility in the environment field.

AB - Fluorescent sensor (DMH) based on dipeptide was efficiently synthesized in solid phase synthesis. The dipeptide sensor shows sensitive response to Ag(I), Hg(II), and Cu(II) among 14 metal ions in 100% aqueous solution. The fluorescent sensor differentiates three heavy metal ions by response type; turn on response to Ag(I), ratiometric response to Hg(II), and turn off detection of Cu(II). The detection limits of the sensor for Ag(I) and Cu(II) were much lower than the EPA's drinking water maximum contaminant levels (MCL). Specially, DMH penetrated live cells and detected intracellular Ag+ by turn on response. We described the fluorescent change, binding affinity, detection limit for the metal ions. The study of a heavy metal-responsive sensor based on dipeptide demonstrates its potential utility in the environment field.

KW - Ag(I)

KW - Fluorescent

KW - Hg(II)

KW - Peptide

KW - Ratiometric

KW - Sensor

UR - https://www.scopus.com/pages/publications/79961127399

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DO - 10.1016/j.talanta.2011.06.052

M3 - Article

AN - SCOPUS:79961127399

SN - 0039-9140

VL - 85

SP - 1566

EP - 1574

JO - Talanta

JF - Talanta

IS - 3

ER -

Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide

Abstract

Bibliographical note

Keywords

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