Abstract
This paper reports a dual-immunopatterned (DIP) device for efficient isolation of the heterogeneous circulating tumor cells (CTCs). The performance of the device, which consists of anti-EpCAM-immobilized patterns (top) and in-house produced anti-63-B6-immobilized patterns (bottom), was verified using epithelial and mesenchymal breast cancer cell, MCF-7 and MDA-MB-231, respectively. The combination of two antibodies in the present devices facilitates isolation of heterogeneous CTCs regardless of epithelial-mesenchymal transition (EMT) process.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 295-296 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| State | Published - 2016 |
| Externally published | Yes |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 |
Publication series
| Name | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|
Conference
| Conference | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country/Territory | Ireland |
| City | Dublin |
| Period | 9/10/16 → 13/10/16 |
Bibliographical note
Funding Information:This research was supported by the Converging Research Center Program funded by the Ministry of Science, ICT and Future Planning (Project No. 2015054201)
Keywords
- Anti-63-B6 antibody
- Circulating tumor cells
- Dual-immunopatterned device
