Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri

Wei Dong Xie; Xia Li; Cheng Wu Weng; Shan Shan Liu; Kyung Ho Row

doi:10.1248/cpb.59.511

Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri

Wei Dong Xie, Xia Li, Cheng Wu Weng, Shan Shan Liu, Kyung Ho Row

Shandong University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC₅₀ values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.

Original language	English
Pages (from-to)	511-514
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	4
DOIs	https://doi.org/10.1248/cpb.59.511
State	Published - 2011

Keywords

Cytotoxicity
Fischerisin A
Fischerisin B
Geranylhydroquinone
Ligularia fischeri
Sesquiterpenoid

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri",

abstract = "During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC50 values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.",

keywords = "Cytotoxicity, Fischerisin A, Fischerisin B, Geranylhydroquinone, Ligularia fischeri, Sesquiterpenoid",

author = "Xie, {Wei Dong} and Xia Li and Weng, {Cheng Wu} and Liu, {Shan Shan} and Row, {Kyung Ho}",

year = "2011",

doi = "10.1248/cpb.59.511",

language = "English",

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pages = "511--514",

journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri

AU - Xie, Wei Dong

AU - Li, Xia

AU - Weng, Cheng Wu

AU - Liu, Shan Shan

AU - Row, Kyung Ho

PY - 2011

Y1 - 2011

N2 - During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC50 values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.

AB - During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC50 values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.

KW - Cytotoxicity

KW - Fischerisin A

KW - Fischerisin B

KW - Geranylhydroquinone

KW - Ligularia fischeri

KW - Sesquiterpenoid

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DO - 10.1248/cpb.59.511

M3 - Article

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SN - 0009-2363

VL - 59

SP - 511

EP - 514

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

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Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri

Abstract

Keywords

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