Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats

Dae Yun Seo, Jun Hyun Bae, Didi Zhang, Wook Song, Hyo Bum Kwak, Jun Won Heo, Su Jeen Jung, Hyeong Rok Yun, Tae Nyun Kim, Sang Ho Lee, Amy Hyein Kim, Dae Hoon Jeong, Hyoung Kyu Kim, Jin Han

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Cisplatin is widely known as an anti-cancer drug. However, the effects of cisplatin on mitochondrial function and autophagy-related proteins levels in the skeletal muscle are unclear. The purpose of this study was to investigate the effect of different doses of cisplatin on mitochondrial function and autophagy-related protein levels in the skeletal muscle of rats. Eight-week-old male Wistar rats (n = 24) were assigned to one of three groups; the first group was administered a saline placebo (CON, n = 10), and the second and third groups were given 0.1 mg/kg body weight (BW) (n = 6), and 0.5 mg/kg BW (n = 8) of cisplatin, respectively. The group that had been administered 0.5 mg cisplatin exhibited a reduced BW, skeletal muscle tissue weight, and mitochondrial function and upregulated levels of autophagy-related proteins, including LC3II, Beclin 1, and BNIP3. Moreover, this group had a high LC3 II/I ratio in the skeletal muscle; i.e., the administration of a high dose of cisplatin decreased the muscle mass and mitochondrial function and increased the levels of autophagy-related proteins. These results, thus, suggest that reducing mitochondrial dysfunction and autophagy pathways may be important for preventing skeletal muscle atrophy following cisplatin administration.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalBMB Reports
Volume54
Issue number11
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021. by the The Korean Society for Biochemistry and Molecular Biology.

Keywords

  • Autophagy
  • Cancer
  • Cisplatin
  • Mitochondrial function
  • Skeletal muscle

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