Abstract
This study aimed to determine the effects of a single bout exercise on mitochondria-mediated apoptotic signaling in cardiac and skeletal muscles. Fischer 344 rats (4 months old) were randomly divided into the control or a single bout of exercise group (n=10 each). The rats per-formed a single bout of treadmill exercise for 60 min. Mitochondria-me-diated apoptotic signaling (e.g., Bax, Bcl-2, mitochondrial permeability transition pore [mPTP] opening, cytochrome c, and cleaved caspase-3) was measured in cardiac (e.g., left ventricle) and skeletal (e.g., soleus and white gastrocnemius) muscles. A single bout of exercise signifi-cantly decreased mPTP opening sensitivity in all tissues. However, a single bout of exercise did not show any statistical differences in Bax, Bcl-2, cytochrome c, and cleaved caspase-3 in all tissues measured. A single bout of exercise did not show definite results on characteristics of mitochondria-mediated apoptotic signaling. Therefore, further re-search is necessary to provide a more mechanistic understanding of the apoptosis pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 512-517 |
| Number of pages | 6 |
| Journal | Journal of Exercise Rehabilitation |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2019 |
Bibliographical note
Publisher Copyright:© 2019 Korean Society of Exercise Rehabilitation.
Keywords
- Apoptosis
- Exercise
- Heart
- Mitochondria
- Skeletal muscle