Abstract
There has been an increasing interest in the development and applications of carbon nanotubes (CNTs) due to their huge potential in industrial and medical applications, but the toxicological properties of these materials have not been well characterized, especially the effects of nanoparticle exposure under different conditions on cellular responses. Nano-structured particles are potentially hazardous when they deposit in the respiratory system. In this study, we characterized the effects of single walled CNT (SWCNT) exposure on interleukin-8 (IL-8) expression in human alveolar epithelial cells (A549) under various exposure conditions. We measured the level of IL-8 expression in the presence and absence of serum following exposure of SWCNTs. The results demonstrated that IL-8 expression was enhanced in the presence of serum. When A549 cells were exposed to low concentrations of SWCNTs, IL-8 expression kept increasing, even after removal of SWCNTs from the media. In addition, SWCNT exposure under dynamic cell growth condition induced changes in IL-8 expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1153-1160 |
| Number of pages | 8 |
| Journal | Toxicology in Vitro |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 2011 |
| Externally published | Yes |
Bibliographical note
Funding Information:Funding for this study was provided by Vice President for Research (VPR) at Utah State University. We also thank Aaron Winder for his help in proof reading this manuscript.
Keywords
- Dynamic cell growth
- Exposure conditions
- IL-8
- Nanotoxicity
- SWCNTs