Dynamic identification and visualization of gene regulatory networks from time-series gene expression profiles

Yu Chen, Kyungsook Han

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Recent improvements in high-throughput proteomics technology have produced a large amount of time-series gene expression data. The data provide a good resource to uncover causal gene-gene or gene-phenotype relationships and to characterize the dynamic properties of the underlying molecular networks for various biological processes. Several methods have been developed for identifying the molecular mechanisms of regulation of genes from the data, but many of the methods consider static gene expression profiles only. This paper presents a new method for identifying gene regulations from the time-series gene expression data and for visualizing the gene regulations as dynamic gene regulatory networks. The method has been implemented as a program called DRN Builder (Dynamic Regulatory Network Builder; http://wilab.inha.ac.kr/drnbuilder/ ) and successfully tested on actual gene expression profiles. DRN Builder will be useful for generating potential gene regulatory networks from a large amount of time-series gene expression data and for analyzing the identified networks.

Original languageEnglish
Title of host publicationEmerging Intelligent Computing Technology and Applications - 5th International Conference on Intelligent Computing, ICIC 2009, Proceedings
Pages65-74
Number of pages10
DOIs
StatePublished - 2009
Event5th International Conference on Intelligent Computing, ICIC 2009 - Ulsan, Korea, Republic of
Duration: 16 Sep 200919 Sep 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5754 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference5th International Conference on Intelligent Computing, ICIC 2009
Country/TerritoryKorea, Republic of
CityUlsan
Period16/09/0919/09/09

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