Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines

Luwei Fang; Minglei Tian; Xuemin Yan; Wei Xiao; Kyung Ho Row

doi:10.1016/j.chroma.2019.01.008

Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines

Luwei Fang, Minglei Tian, Xuemin Yan, Wei Xiao, Kyung Ho Row

Yangtze University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A convenient, and efficient multi-phase extraction method was used to isolate aristolochic acid from real samples. To increase the efficiency, a new dual ionic liquid-immobilized silica was used as a sorbent and the effects of the adsorption conditions were investigated. IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60 °C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined. The sorbent was then applied to the multi-phase extraction of aristolochic acid. After extraction eight times, 2.4–70.9 × 10 ⁻³ mg/g of aristolochic acid was isolated from nine real samples after several washing and elution steps. The recoveries of aristolochic acid ranged from 70.0% to 110.6% with relative standard deviations of 3.5%–9.1%, highlighting the accuracy of this method.

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Journal of Chromatography A
Volume	1592
DOIs	https://doi.org/10.1016/j.chroma.2019.01.008
State	Published - 10 May 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Aristolochic acid
Dual ionic liquid
Herbal
Isolation
Multi-phase extraction

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10.1016/j.chroma.2019.01.008

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title = "Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines",

abstract = " A convenient, and efficient multi-phase extraction method was used to isolate aristolochic acid from real samples. To increase the efficiency, a new dual ionic liquid-immobilized silica was used as a sorbent and the effects of the adsorption conditions were investigated. IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60 °C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined. The sorbent was then applied to the multi-phase extraction of aristolochic acid. After extraction eight times, 2.4–70.9 × 10 −3 mg/g of aristolochic acid was isolated from nine real samples after several washing and elution steps. The recoveries of aristolochic acid ranged from 70.0% to 110.6% with relative standard deviations of 3.5%–9.1%, highlighting the accuracy of this method.",

keywords = "Aristolochic acid, Dual ionic liquid, Herbal, Isolation, Multi-phase extraction",

author = "Luwei Fang and Minglei Tian and Xuemin Yan and Wei Xiao and Row, {Kyung Ho}",

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year = "2019",

month = may,

day = "10",

doi = "10.1016/j.chroma.2019.01.008",

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T1 - Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines

AU - Fang, Luwei

AU - Tian, Minglei

AU - Yan, Xuemin

AU - Xiao, Wei

AU - Row, Kyung Ho

PY - 2019/5/10

Y1 - 2019/5/10

N2 - A convenient, and efficient multi-phase extraction method was used to isolate aristolochic acid from real samples. To increase the efficiency, a new dual ionic liquid-immobilized silica was used as a sorbent and the effects of the adsorption conditions were investigated. IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60 °C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined. The sorbent was then applied to the multi-phase extraction of aristolochic acid. After extraction eight times, 2.4–70.9 × 10 −3 mg/g of aristolochic acid was isolated from nine real samples after several washing and elution steps. The recoveries of aristolochic acid ranged from 70.0% to 110.6% with relative standard deviations of 3.5%–9.1%, highlighting the accuracy of this method.

AB - A convenient, and efficient multi-phase extraction method was used to isolate aristolochic acid from real samples. To increase the efficiency, a new dual ionic liquid-immobilized silica was used as a sorbent and the effects of the adsorption conditions were investigated. IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60 °C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined. The sorbent was then applied to the multi-phase extraction of aristolochic acid. After extraction eight times, 2.4–70.9 × 10 −3 mg/g of aristolochic acid was isolated from nine real samples after several washing and elution steps. The recoveries of aristolochic acid ranged from 70.0% to 110.6% with relative standard deviations of 3.5%–9.1%, highlighting the accuracy of this method.

KW - Aristolochic acid

KW - Dual ionic liquid

KW - Herbal

KW - Isolation

KW - Multi-phase extraction

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DO - 10.1016/j.chroma.2019.01.008

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SN - 0021-9673

VL - 1592

SP - 31

EP - 37

JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines

Abstract

Bibliographical note

Keywords

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