Design and synthesis of metallopeptide sensors: Tuning selectivity with ligand variation

Joung Min Kim, Bishnu Prasad Joshi, Keun Hyeung Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We chose a fluorescent pentapeptide sensor (-CPGHE) containing a dansyl fluorophore as a model peptide and investigated whether the selectivity and sensitivity of the peptides for heavy and transition metal ions could be tuned by changing amino acid sequence. In this process, we developed a selective peptide sensor, Cp1-d (-HHPGE, Kd = 670 nM) for detection of Zn 2+ in 100% aqueous solution and a selective and sensitive peptide sensor, Cp1-e (-CCHPGE, Kb = 24 nM) for detection of Cd2+ in 100% aqueous solution. Overall results indicate that the selectivity and sensitivity of the metallopeptide sensors to specific heavy and transition metal ions can be tuned by changing amino acid sequence.

Original languageEnglish
Pages (from-to)2537-2541
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume31
Issue number9
DOIs
StatePublished - 20 Sep 2010

Keywords

  • Cd
  • Chemical sensor
  • Peptide sensor
  • Peptides
  • Zn

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