Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

Kyeong Jin Kim; Kook Hwan Kim; Hye Young Kim; Hyun Kook Cho; Naoya Sakamoto; Jae Hun Cheong

doi:10.1016/j.febslet.2009.12.019

Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

Kyeong Jin Kim, Kook Hwan Kim, Hye Young Kim, Hyun Kook Cho, Naoya Sakamoto, Jae Hun Cheong

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.

Original language	English
Pages (from-to)	707-712
Number of pages	6
Journal	FEBS Letters
Volume	584
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2009.12.019
State	Published - Feb 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund) ( KRF-2008-313-C00656 ).

Keywords

Akt
Curcumin
HCV
NS5A
SREBP-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2009.12.019

Cite this

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title = "Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway",

abstract = "A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.",

keywords = "Akt, Curcumin, HCV, NS5A, SREBP-1",

author = "Kim, {Kyeong Jin} and Kim, {Kook Hwan} and Kim, {Hye Young} and Cho, {Hyun Kook} and Naoya Sakamoto and Cheong, {Jae Hun}",

note = "Funding Information: This work was supported by National Research Foundation of Korea Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund) ( KRF-2008-313-C00656 ).",

year = "2010",

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doi = "10.1016/j.febslet.2009.12.019",

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AU - Kim, Kook Hwan

AU - Kim, Hye Young

AU - Cho, Hyun Kook

AU - Sakamoto, Naoya

AU - Cheong, Jae Hun

N1 - Funding Information: This work was supported by National Research Foundation of Korea Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund) ( KRF-2008-313-C00656 ).

PY - 2010/2

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N2 - A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.

AB - A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.

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KW - HCV

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Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

Abstract

Bibliographical note

Keywords

UN SDGs

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