@inbook{a2d1eba00c7f41dc906d9f70252af9ea,
title = "Computational identification of-1 frameshift signals",
abstract = "Ribosomal frameshifts in the -1 direction are used frequently by RNA viruses to synthesize a single fusion protein from two or more overlapping open reading frames. The slippery heptamer sequence XXX YYY Z is the best recognized of the signals that promote -1 frameshifting. We have developed an algorithm that predicts plausible -1 frameshift signals in long DNA sequences. Our algorithm is implemented in a working program called FSFinder (Frameshift Signal Finder). We tested FSFinder on 72 genomic sequences from a number of organisms and found that FSFinder predicts -1 frameshift signals efficiently and with greater sensitivity and selectivity than existing approaches. Sensitivity is improved by considering all potentially relevant components of frameshift signals, and selectivity is increased by focusing on overlapping regions of open reading frames and by prioritizing candidate frameshift signals. FSFinder is useful for analyzing -1 frameshift sienals as well as discoverins unknown genes.",
author = "Sanghoon Moon and Yanga Byun and Kyungsook Han",
year = "2004",
doi = "10.1007/978-3-540-24685-5_42",
language = "English",
isbn = "9783540221142",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "334--341",
editor = "Marian Bubak and {van Albada}, {Geert Dick} and Sloot, {Peter M.A.} and Dongarra, {Jack J.}",
booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
address = "Germany",
}