Abstract
Dispersive liquid–liquid microextraction using deep eutectic solvents, as novel extraction solvents, was developed for the separation, preconcentration, and determination of chlorophenol, 2,3-dihydroxybenzoic acid, p-cresol, 4-chlorophenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol in vegetable oil. Seven deep eutectic solvents composed of choline chloride and different hydrogen bond donors (ethyl glycol, glycerol, 1,2-butanediol, 1,4-butanediol, 1,6-hexanediol, urea, and acetic acid) were characterized. The deep eutectic solvents formed by choline chloride-1,6-hexanediol in a 1:2 molar ratio provided the highest extraction efficiency. The sonication time, deep eutectic solvent volume, and disperser solvent were optimized. Under the optimal conditions of a sonication time of 11 min, a deep eutectic solvent volume of 90 µL, and acetone as the disperser solvent, extraction recoveries from 76.1 to 88.3% were obtained with 8.46 to 9.46 enrichment factors and the limits of detection exceeding 0.1 µg/mL with the relative standard deviations from 1.0 to 3.5%. This method using dispersive liquid–liquid microextraction with deep eutectic solvents is simple and provides high enrichment.
Original language | English |
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Pages (from-to) | 2177-2188 |
Number of pages | 12 |
Journal | Analytical Letters |
Volume | 50 |
Issue number | 14 |
DOIs | |
State | Published - 22 Sep 2017 |
Bibliographical note
Publisher Copyright:© 2017 Taylor & Francis.
Keywords
- Chlorophenol
- deep eutectic solvent
- dispersive liquid–liquid microextraction
- high-performance liquid chromatography
- phenolics