Characterization of Deep Eutectic Solvents for Dispersive Liquid–Liquid Microextraction for Phenolics

Wanwan Ma, Weiyang Tang, Kyung Ho Row

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Dispersive liquid–liquid microextraction using deep eutectic solvents, as novel extraction solvents, was developed for the separation, preconcentration, and determination of chlorophenol, 2,3-dihydroxybenzoic acid, p-cresol, 4-chlorophenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol in vegetable oil. Seven deep eutectic solvents composed of choline chloride and different hydrogen bond donors (ethyl glycol, glycerol, 1,2-butanediol, 1,4-butanediol, 1,6-hexanediol, urea, and acetic acid) were characterized. The deep eutectic solvents formed by choline chloride-1,6-hexanediol in a 1:2 molar ratio provided the highest extraction efficiency. The sonication time, deep eutectic solvent volume, and disperser solvent were optimized. Under the optimal conditions of a sonication time of 11 min, a deep eutectic solvent volume of 90 µL, and acetone as the disperser solvent, extraction recoveries from 76.1 to 88.3% were obtained with 8.46 to 9.46 enrichment factors and the limits of detection exceeding 0.1 µg/mL with the relative standard deviations from 1.0 to 3.5%. This method using dispersive liquid–liquid microextraction with deep eutectic solvents is simple and provides high enrichment.

Original languageEnglish
Pages (from-to)2177-2188
Number of pages12
JournalAnalytical Letters
Volume50
Issue number14
DOIs
StatePublished - 22 Sep 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis.

Keywords

  • Chlorophenol
  • deep eutectic solvent
  • dispersive liquid–liquid microextraction
  • high-performance liquid chromatography
  • phenolics

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