Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Mallikarjuna N. Nadagouda; Pooja Vijayasarathy; Aebin Sin; Heeyeon Nam; Sanaullah Khan; Javad B.M. Parambath; Ahmed A. Mohamed; Changseok Han

doi:10.1007/s00044-022-02924-9

Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Mallikarjuna N. Nadagouda, Pooja Vijayasarathy, Aebin Sin, Heeyeon Nam, Sanaullah Khan, Javad B.M. Parambath, Ahmed A. Mohamed, Changseok Han

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	1663-1678
Number of pages	16
Journal	Medicinal Chemistry Research
Volume	31
Issue number	10
DOIs	https://doi.org/10.1007/s00044-022-02924-9
State	Published - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Antibacterial activities
Biofilms
Disinfectants
Quaternary ammonium salts

Access to Document

10.1007/s00044-022-02924-9

Cite this

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title = "Antimicrobial activity of quaternary ammonium salts: structure-activity relationship",

abstract = "Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [Figure not available: see fulltext.].",

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AU - Vijayasarathy, Pooja

AU - Sin, Aebin

AU - Nam, Heeyeon

AU - Khan, Sanaullah

AU - Parambath, Javad B.M.

AU - Mohamed, Ahmed A.

AU - Han, Changseok

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N2 - Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [Figure not available: see fulltext.].

AB - Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [Figure not available: see fulltext.].

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KW - Disinfectants

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Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Abstract

Bibliographical note

Keywords

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