Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Mallikarjuna N. Nadagouda, Pooja Vijayasarathy, Aebin Sin, Heeyeon Nam, Sanaullah Khan, Javad B.M. Parambath, Ahmed A. Mohamed, Changseok Han

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1663-1678
Number of pages16
JournalMedicinal Chemistry Research
Volume31
Issue number10
DOIs
StatePublished - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Antibacterial activities
  • Biofilms
  • Disinfectants
  • Quaternary ammonium salts

Fingerprint

Dive into the research topics of 'Antimicrobial activity of quaternary ammonium salts: structure-activity relationship'. Together they form a unique fingerprint.

Cite this