Research output per year
Research output per year
Personal profile
Education
(2005) B.S., Genetic Engineering, Kyung Hee University, Korea
(2013) Ph.D., Molecular Biology and Genetics, Seoul National University, Korea
(2013) Ph.D., Molecular Biology and Genetics, Seoul National University, Korea
Professional Experience
(2019~Present) Assistant Professor, Inha University, Korea
(2014~2019) Postdoctoral Fellow, MD Anderson Cancer Center, USA
(2013~2014) Senior researcher, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Korea
(2014~2019) Postdoctoral Fellow, MD Anderson Cancer Center, USA
(2013~2014) Senior researcher, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Korea
Research Interests
Cancer Biology, Anti-tumor immunity, Immunogenic cell death, Therapeutic Antibody & Antibody drug conjugates, Immune checkpoint, Cancer immunotherapy
Major Research Achievements
Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer Journal of Biological Chemistry, 2022 Mar 9;101817. doi: 10.1016/j.jbc.2022.
New approaches on cancer immunotherapy. Cold Spring Harbor Perspectives in Medicine. 2020 Aug 3;10(8):a036863. doi: 10.1101/cshperspect.a036863.
Mechanisms controlling PD-L1 expression in cancer Molecular Cell. 2019 Nov. 7; 76:1-12
Metformin promotes antitumor immunity via endoplasmic reticulum-associated degradation of PD-L1. Molecular Cell. 2018;71(4):606-620.
Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression. Cancer Research. 2018;78(14):3761-3768.
Prompt meningeal reconstruction by oxygen-sensitive AKAP12 scaffolding protein after CNS injury. Nature Communications. 2014;5:4952
New approaches on cancer immunotherapy. Cold Spring Harbor Perspectives in Medicine. 2020 Aug 3;10(8):a036863. doi: 10.1101/cshperspect.a036863.
Mechanisms controlling PD-L1 expression in cancer Molecular Cell. 2019 Nov. 7; 76:1-12
Metformin promotes antitumor immunity via endoplasmic reticulum-associated degradation of PD-L1. Molecular Cell. 2018;71(4):606-620.
Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression. Cancer Research. 2018;78(14):3761-3768.
Prompt meningeal reconstruction by oxygen-sensitive AKAP12 scaffolding protein after CNS injury. Nature Communications. 2014;5:4952
URL
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Splicing factor SF3B4 acts as a switch in cancer cell senescence by regulating p21 mRNA stability
Kang, D., Sung, J. Y., Hwang, H. J., Baek, Y., Kim, M. J., Lim, G. E., Kim, Y. N., Cha, J. H. & Lee, J. S., 10 Apr 2025, In: Cancer Letters. 615, 217530.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Therapy-induced senescent cancer cells contribute to cancer progression by promoting ribophorin 1-dependent PD-L1 upregulation
Hwang, H. J., Kang, D., Shin, J., Jung, J., Ko, S., Jung, K. H., Hong, S. S., Park, J. E., Oh, M. J., An, H. J., Yang, W. H., Ko, Y. G., Cha, J. H. & Lee, J. S., Dec 2025, In: Nature Communications. 16, 1, 353.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer
Hong, S. M., Lee, A. Y., Kim, B. J., Lee, J. E., Seon, S. Y., Ha, Y. J., Ng, J. T., Yoon, G., Lim, S. B., Morgan, M. J., Cha, J. H., Lee, D. & Kim, Y. S., 10 Apr 2024, In: Advanced Science. 11, 14, 2303177.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
PD-L1: From cancer immunotherapy to therapeutic implications in multiple disorders
Lee, D., Cho, M., Kim, E., Seo, Y. & Cha, J. H., 4 Dec 2024, In: Molecular Therapy. 32, 12, p. 4235-4255 21 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
TESC associated with poor prognosis enhances cancer stemness and migratory properties in liver cancer
Ye, P., Luo, S., Huang, J., Fu, X., Chi, X., Cha, J. H., Chen, Y., Mai, Y., Hsu, K. W., Yan, X. & Yang, W. H., Dec 2024, In: Clinical and Experimental Medicine. 24, 1, 206.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations